ICJR Interviews: Is Cefazolin the Right Choice for Antibiotic Prophylaxis?

    Unless the patient has a MRSA infection and needs vancomycin, cefazolin is the go-to broad-spectrum antibiotic administered preoperatively to prevent periprosthetic joint infection in patients undergoing total hip or total knee arthroplasty.

    Should it be? Or should the surgeon take into account the patient’s comorbidities and tailor the preop regimen?

    That’s the question asked by Antonia Chen, MD, MBA, and her colleagues at The Rothman Institute in Philadelphia, Pennsylvania. Fortunately, they have access to a large database on infections that have developed after total joint replacement and can mine it for answers to these types of questions.

    We asked Dr. Chen to share the results of the study, “Should Preoperative Antibiotics be Tailored According to Patient’s Comorbidities?” (Paper 572), which was presented at the 2016 Annual Meeting of the American Academy of Orthopaedic Surgeons in Orlando.

    Click the image above to hear her comments.

    Producer: Susan Doan-Johnson; Director and Post Production: Charles J. Maynard